Jacksonville will be full of confidence after their extraordinary comeback and look a great bet with the points at Kansas City.
An old rivalry resumes when Dallas and San Francisco square off as they did last year and so often in the 1990s when both vied for NFC supremacy.
It is an all NFC East battle when the New York Giants travel to Philadelphia to meet division rivals the Eagles in a match-up that has plenty to it.
The final game of Wildcard Weekend may well be the most compelling with Tom Brady in potentially his final game hosting a Dallas Cowboys with the spectre of another year of underachievement looming.
The closest betting match of Wildcard Weekend sees the Jacksonville Jaguars end their playoff drought in hosting the LA Chargers.
The Bengals comfortably beat the Ravens last weekend and should do so again in the first week of the playoffs.
The Vikings are complete frauds and it would not surprise to see the Giants upset the NFC North champions.
The line here looks just a little bit too big even with the Dolphins playing their third string quarterback.
The playoffs for the 2022 season opens with an all-NFC West clash with the San Francisco 49ers set to do a job on rivals the Seattle Seahawks in what looks a major mismatch.
The regular season draws to a close with Detroit travelling to Lambeau to take on Green Bay. The Packers need to win to make the playoffs while it could be the same scenario for the Lions if the Rams upset the Seahawks earlier.