Round 3 closes with a must-win game for a winless Fremantle against their bitter crosstown rivals, West Coast.
The red hot Crows host the 1-1 Roos on Sunday afternoon in what should be a total shootout.
Rain could play havoc when the Cats travel north to play the Lions in a rescheduled game from Opening Round.
The Saints should go to 2-1 on the season when they host Richmond at Marvel on Saturday afternoon.
The Hawks host the Giants in Launceston on Saturday night in a blockbuster match-up between two 2025 flag contenders.
The Dees have dominated the Suns for years but that streak may come to an end on Saturday at the MCG.
The Blues are still in search of their first win of 2025 but it won't come easy against the Bulldogs on Friday night.
Bombers fans will be hoping for a strong response when their side host Port Adelaide at Marvel Stadium on Thursday night.
The final match of Round 2 is probably the match of the round, with the Dockers hosting the Swans at Optus Stadium.
West Coast are in for another tough challenge when they travel to Brisbane to face the reigning premiers.
The blowouts could continue on Saturday night when St Kilda host Geelong at Marvel Stadium.
The Power will be desperate to atone from their Round 1 belting when they host a Richmond team coming off a stunning victory.
Adelaide look set to continue their hot start to 2025 against the Bombers at the MCG on Saturday afternoon.
Footscray mark 100 years in the VFL/AFL on Friday night, but against Collingwood, the celebrations may be short-lived.
Carlton will be looking to bounce back from a disastrous Round 1 loss when they face the 2-0 Hawks on Thursday night.
The final game of AFL Round 1 sees the Eagles hosting the Suns at Optus Stadium.
Rain is set to play spoiler on Sunday's MCG clash between Melbourne and GWS, but it does present some good betting opportunities.
After disappointing seasons in 2024, both the Saints and Crows will be looking to get off to a winning start in Adelaide on Sunday.
The Pies will be looking to bounce back from a flat start against Port Adelaide on Saturday night at the MCG.